Researchers in the Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso along with other researchers at the University of Missouri School of Medicine, (UMSOM) in Kansas City, Missouri, and at Medical University of Lublin, Lublin, Poland have received accolades for their paper entitled: “Stimulation of Mucin, Mucus & Viscosity During Lubiprostone in Patients with Chronic Constipation May Potentially Lead to Increase of Lubrication.”
The research based on an pioneering clinical trial exploring whether lubiprostone, a novel chloride channel ClC-2 activator, increases the rate of mucus and mucin secretion and its viscosity in chronic constipation patients, was published a few weeks ago in the journal Clinical & Translational Gastroenterology (CTG) and highlighted in American College of Gastroenterology (ACG) Smart Brief weekly.
Research was conducted by Irene Sarosiek, M.D., associate professor, Jerzy Sarosiek, M.D., Ph.D. professor of medicine, both in the Department of Internal Medicine, TTUHSC El Paso; Marek Majewski, M.D., Ph.D., assistant professor of surgery, Grzegorz Wallner, M.D., Ph.D. professor of surgery, both at the Medical University of Lublin, Lublin, Poland and Stanley Edlavitch, Ph.D., professor of epidemiology and biostatistics, UMSOM, KC, MO.
CTG, published on behalf of the ACG, is a peer-reviewed, open-access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology.
The full article can be seen at: http://www.nature.com/ctg/journal/v5/n12/full/ctg201419a.html.
This publication confirms a previously published ground-breaking study of this team demonstrating that in patients with chronic constipation, a significantly lower rate of mucus and mucin secretion accompanied by significant impairment of viscosity may represent an impairment of lubrication within the alimentary tract as a pathogenetic link to their symptoms; published in November 2014 issue of Digestive Diseases & Science (vol. 59:2730-2743). Juan Castro-Combs, M.D., a 2nd year GI Fellow and Cesar J. Garcia, M.D., a 3rd year GI Fellow, Division of Gastroenterology, Department of Internal Medicine, TTUHSC El Paso are the leading authors of this previous study and publication.